Costei AM, Kozer E, Ho T; Ito S; Koren G. Perinatal Outcome Following Third Trimester Exposure to Paroxetine  Arch Pediatr Adolesc Med. 2002;156:1129-1132

This important, prospective, controlled cohort study is the first to compare outcomes in women exposed to an SSRI during the last trimester of pregnancy with matched controls. "Of the 55 neonates exposed to paroxetine in late gestation, 12 had complications necessitating intensive treatment and prolonged hospitalisation. The most prevalent clinical picture was respiratory distress (n=9), followed by hypoglycaemia (n=2) and jaundice (n=1). The symptoms disappeared within 1 to 2 weeks. In the comparison group, only 3 infants experienced complications (p=.03)."

Contents page
What's New?